But now it is accepted as important site for drug delivery. In addition, the system must provide protection for the drug during transit to the colon. Physical, chemical and biological by hans schreier pdf. Colontargeted drug delivery differs from ordinary enteric coatings that are designed to merely avoid drug release in the stomach in that the tablet or capsule is specially formulated to channel greater quantity of drug release to the colonic compartment, thus preventing or highly reducing drug release until the dosage form reaches the colon. In recent years, the global pharmaceutical market for biologics has. Colonic drug delivery has gained increased importance not just for the delivery of the drugs for the treatment of. Formulation development and evaluation of drug release. Colonic targeting of metronidazole using azo aromatic polymers, development and. Day by day there are new developments in field of colon specific drug delivery system. Apart from retarding or targeting dosage forms, a reliable colonic drug delivery could also be an important starting position for the colonic absorption, undigested, unchanged and fully active peptide drugs 15. Drug targeting to the colon with lectins and neoglycoconjugates drug targeting to the colon with lectins and neoglycoconjugates minko, tamara 20040303 00. Need of colon targeted drug delivery system to ensure direct treatment at the disease site, lower dosing and fewer systemic side effects.
Colon targeted drug delivery systems a potential approach nishant singh and dr. Jun 26, 2009 specific targeting of drugs to the colon is recognized to have several therapeutic advantages. Drugs which are destroyed by the stomach acid andor metabolized by pancreatic enzymes are. Occurrence of inflammatory bowel diseases has increased at an alarming rate. Solubility, swelling index, viscosity, and ph of the polymer solution were determined. Read evaluation of guar gum as a compression coat for drug targeting to colon, international journal of pharmaceutics on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Colonic drug delivery has gained increased importance not just for the delivery of the drugs for the treatment of local diseases associated with the colon but also for its potential for the delivery of proteins and therapeutic peptides. Sep 17, 2012 targeting drugs and delivery systems to the colonic region of the gastrointestinal tract has received considerable interest in recent years. Development of modified pulsincap drug delivery system of. Colon drug delivery system authorstream presentation.
Colonic drug targeting approaches for treatment of inflammatory bowel disease. Rajpurohit, et al polymers for colon targeted drug delivery the colon targeted drug delivery has a number of important implications in the field of pharmacotherapy. Peptides, proteins, oligonucleotides and vaccines pose potential candidature for colon targeted drug delivery. Thanks for helping us catch any problems with articles on deepdyve. Rheological characterization of the hydrogel formation and the hydrogel network. The results of the study indicated that under simulated colonic conditions, drug release was more pronounced from coated formulations containing higher proportion of pectin. As an emerging approach to block cytokines, antisense oligonucleotide aso has developed quickly, but is thwarted by a key obstaclesafe and effective delivery to specified cells. Additional interest in colon targeted drug delivery system has generated from the potential of the colonic site for the entry of some drugs into the systemic circulation. Colonic drug delivery has gained increased importance not. We aim to use the phospholipase a2 pla2, an enzyme that is overexpressed in the inflamed colonic tissues of. Gastro intestinal transit time gastro intestinal transit time. Targeted drug delivery system targeting of drugs is a special form of dds in which the pharmacological active ingredients or drugs that selectively targeted or delivered only at the site of action or absorption site and not to nontarget organs or tissues cells are normal. Targeting of drugs to the colon via oral administration protect the drug from degradation or release in the stomach and small intestine.
International license, which allows users to download, copy and build upon published articles even for commercial purposes, as long as the author and publisher are properly credited. Emerging techniques and challenges in colon drug delivery. Colonspecific drug delivery systems cdds are desirable for the treatment of a range of local diseases such as ulcerative colitis, crohns disease, irritable bowel syndrome, chronic pancreatitis, and colonic cancer. Colon targeted drug delivery systems the pharma innovation journal. Download hires image download to mspowerpoint cite this. In addition, the colon can be a potential site for the systemic absorption of several drugs to treat noncolonic conditions. This means of delivery is largely founded on nanomedicine, which plans to employ nanoparticlemediated drug delivery in order to combat the downfalls of conventional drug. A 2 4 factorial design was carried out to optimize the preparation conditions. The results of the study show that matrix tablets containing 20% of guar gum are most likely to provide targeting of nitrofurantoin in the colon. Pdf nanoparticlebased oral drug delivery systems targeting. For simulating the human physiological environment of the colon, appropriate animal model selection is depends on its approach and design of system. In vivo performance in rats, international journal of pharmaceutics on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Colon targeting colonic drug delivery uses pharmacology. Apr 21, 2011 various strategies used for targeting drugs to the colon include formation of a prodrug, coating with time or phdependent polymers, use of colonspecific biodegradable polymers, osmotic systems and pressurecontrolled drug delivery systems. Nov 21, 2017 but now it is accepted as important site for drug delivery. Animal models rats, mice, pigs and dogs animal models were reported for colon targeted drug delivery systems. Novel approaches to colon targeted drug delivery system. This approach shows promising results in the colon drug delivery system as it. Download as pdf about authors sumedha saxena, chandan kumar singh, mukeshyadav, alex laurel samson. Colon targeting colonic drug delivery uses pharmacology study material project thesis title pdf doc colon targeting colonic drug delivery uses pharmacology study material project thesis title.
This targeted delivery option has received increased attention not only for treatment of colonspecific diseases such as irritable bowel disease ibd, but also to take advantage of the colons absorptive surface area and conditions to deliver specific drugs and treat specific indications. Colon targeted drug delivery systems a potential approach. Previous studies have shown that albumin has a high affinity towards tumours, and, as a result, many drugalbumin conjugates, as. Issuu is a digital publishing platform that makes it simple to publish magazines, catalogs, newspapers, books, and more online. It should be considered as beneficial in the treatment of colon diseases. Significant progress has been made toward developing a truly selective drug delivery system that targets the site of inflammation in uc. Drug targeting to the colonic area is not only associated with the treatment. Its colonic delivery offers a number of advantages, such as prevention of its adverse gastric effects, targeting to its site of action, for example if the drug is developed for its preventive action in colon cancer jasmeet and nath, 2010, kaur saini et al. Objectives the main objective of targeting the drug to achieve the desired pharmacological response in only one location. However, the targeting of oral drugs to the colon, which is. Treatment of colon can be made effective if the drug can be targeted directly into the colon because drug release and absorption should not be take in abdomen and the small intestine and bioactive agents should not be degraded and to allow drug release into the colon. Targeted drug delivery, sometimes called smart drug delivery, is a method of delivering medication to a patient in a manner that increases the concentration of the medication in some parts of the body relative to others. Nanoparticlebased oral drug delivery systems targeting the colon for treatment of ulcerative colitis. Targeting drugs and delivery systems to the colonic region of the gastrointestinal tract has received considerable interest in recent years.
Formulation and evaluation of colon targeted drug delivery. For example, guinea pigs have glycosidase and glucuronidase. From the invitro dissolution studies it can be discussed that the colon targeted matrix tablet containing 20% guar gum was the best formulation to target the nitrofurantoin to the colon. Pharmaceutics free fulltext regional intestinal drug. Scientific endeavour in this area has been driven by the need to better treat local disorders of the colon such as inflammatory bowel disease ulcerative colitis and crohns disease, irritable bowel syndrome and carcinoma. Colon targeted drug delivery systems have gained a great deal of attention as potential carriers for the local treatment of colonic diseases with reduced systemic side effects and also for the enhanced oral delivery of various therapeutics vulnerable to acidic and enzymatic degradation in the upper gastrointestinal tract. Microflora degradation studies of sterculia gum was conducted in phosphatebuffered saline ph 7. Here a novel nanocomplex, based on galactosylated low molecular weight. From the invitro dissolution studies it can be discussed that the colon targeted matrix tablet containing 20% guar gum was the best formulation to. Preclinically, colonic absorption is often investigated using the rat singlepass intestinal perfusion model.
Formulation and evaluation of colon targeted drug delivery system. When studies were continued in colonic fluids, matrix tablets released almost 100% drug. Srinath department of pharmaceutics, government college of pharmacy, no. The colon is a promising site for drug targeting owing to its long transit time and mild proteolytic activity. Colon targeted drug delivery system a novel perspective by bhushan prabhakar kolte. Certain drugs can be conjugated to different sugar moieties to form glycosides. This targeting of drug to the disease site lowers the. Colonic drug delivery has gained increased importance not just for the delivery of the drugs for the. M college of pharmacy, bahadurgarh, haryana, india day by day there are new developments in field of colon specific drug delivery system. Review article colontargeted oral drug delivery systems core. Demonstrates how substitution of quite a few ligands can render albumin a flexible focusing on software for selective drug accumulation in a variety of phone populations of the liver. To achieve successful colonic delivery, a drug needs to be protected from. The purpose of this research is to evaluate sterculia urens gum as a carrier for a colontargeted drug delivery system. Furthermore, colonic drug delivery has gained increased importance not just for the treatment of local diseases.
Prodrug targeted drug delivery system include three components. Carousel previous carousel next 52ifrj 2017, sri winarti, colonic microbiota. The colon is having high water absorption capacity, the colonic contents are considerably viscous and their mixing is not efficient. The colon is a site where local delivery allows topical treatment of inflammatory bowel disease and systemic delivery of. Colon targeted drug delivery, nitrofurantoin, invitro dissolution, guar gum, rat caecal content. In this work, we present a novel phospholipid plbased prodrug approach, as a tool for colonic drug targeting in uc. Wo2007122374a8 pctgb20070054 gb20070054w wo2007122374a8 wo 2007122374 a8 wo2007122374 a8 wo 2007122374a8 gb 20070054 w gb20070054 w gb 20070054w wo 2007122374 a8 wo2007122374 a8 wo 2007122374a8 authority wo wipo pct prior art keywords drug delivery delivery formulation colonic drug ph material prior art date 200604 application number. Colonic drug targeting approaches for treatment of. The use of naturally occurring polysaccharides is attracting a lot of attention for drug targeting the colon since these polymers of monosaccharides are found in abundance, have wide availability are inexpensive and are available in a verity of a structures with. Drug targeting to the colonic area is not only associated with the treatment of colonic ailment. Colonic drug delivery has gained increased importance not just for the delivery of the drugs for the treatment of local diseases associated with the. Find, read and cite all the research you need on researchgate.
To reach the colon and to be able to specifically deliver and absorb the drug there, the dosage forms must be formulated taking into account the obstacles of the gastrointestinal tract. In order to achieve effective therapeutic outcomes, it is imperative that the designed delivery system specifically targets the drugs into the colon. Advances in colontargeted nanodrug delivery systems. Alginate microparticles as oral colon drug delivery device. Pdf in the recent year colonic drug delivery is important for delivery of drug for. Phospholipidbased prodrugs for colontargeted drug delivery. A novel coating concept for ileocolonic drug targeting. Integrated drug delivery for ulcerative colitis treatment. Significantly reduce overall drug toxicity whilemaintaining therapeutic benefits.
Targeted drug delivery into the colon is highly desirable for local treatment of a variety of bowel diseases such as ulcerative colitis, crohns disease, amebiosis, colonic cancer, local treatment of colonic pathologies, and systemic delivery of protein and peptide drugs. Fifteen years of research in the area of colonspecific drug delivery has left us with a slim choice of viable techniques. Nemade mahesh s, chaudhari rajesh y, and patil vijay r. This targeting of drug to the disease site lowers the requirement of higher doses of drug thus reducing the dosage frequency and cost of the drugs.
View enhanced pdf access article on wiley online library html view download pdf for. Colon targeting is naturally of value for the topical treatment of diseases of colon such as chrons diseases, ulcerative colitis, colorectal cancer and amebiasis. The design of such a system requires the identification and exploitation of a unique feature of the colonic environment. Sufficient colonic absorption is necessary for all systemically acting drugs in dosage forms that release the drug in the large intestine. Targeting colon drug delivery by natural products intechopen. Polymers for colon targeted drug delivery pharmaquest.
Drug targeting to the colonic area is not only associated with the treatment of colonic ailment locally but also delivering drugs such as protein and peptide for their systemic effects which are degraded and bioavailability is very. Colon targeted dds free download as powerpoint presentation. Evaluation of guar gum as a compression coat for drug. In ulcerative colitis uc, the inflammation is localized in the colon, and one of the successful strategies for colon targeting drug delivery is the prodrug approach. Colonic drug delivery has gained increased importance not just for the delivery of the drugs for the treatment of local diseases associated with the colon like crohns disease, ulcerative colitis, etc. Jun, 2015 colonspecific drug delivery systems cdds are desirable for the treatment of a range of local diseases such as ulcerative colitis, crohns disease, irritable bowel syndrome, chronic pancreatitis, and colonic cancer. Near ir fluorescent polystyrenealbumin coreshell nanoparticles for specific targeting of colonic neoplasms. Capsugel offers multiparticulate and capsulecoating technologies to achieve colonic drug delivery. Drugs such as proteins and peptides that are known. Nanoparticlebased oral drug delivery systems targeting the. These metrics are regularly updated to reflect usage leading up to the last few days. Research paperpaper development of modified pulsincap drug delivery system of metronidazole for drug targeting sindhu abraham and m. Sitespecific delivery of drugs to the colon has gained increased importance for localized treatment of several colonic disorders, mainly colorectal. Colonspecific formulation could also be used to prolong the drug delivery.
However, nanotechnological approaches could also be adapted to crohns disease by targeting drugloaded nanoparticles to both the small intestine an additional site of this disease and the large intestine. Easily share your publications and get them in front of issuus. Strategic approaches for colon targeted drug delivery. The use of transit times, ph and bacterial enzymes are critically assessed. This pdf is available for free download from a site hosted by medknow publications. Pharmaceutical approaches to colon targeted drug delivery. Specific targeting of drugs to the colon is recognized to have several therapeutic advantages. Studies on stercuia gum formulations in the form of.
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